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KMID : 1035620180060010041
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Allergy Asthma & Respiratory Disease
2018 Volume.6 No. 1 p.41 ~ p.46
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Relationship of serum vitamin D and interleukin-31 levels to allergic or nonallergic rhinitis in children
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Park Seong-Jun
Soh Ji-Eun
Park Moon-Soo
Jung Hye-Lim
Shim Jae-Won
Kim Duk-Soo
Shim Jung-Yeon
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Abstract
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Purpose: Serum vitamin D (25-hydroxyvitamin D, 25[OH] D) and interleukin-31 (IL-31) are related to atopic dermatitis, but their relationship with allergic rhinitis is unclear. The purpose of this study was to compare the levels of serum IL-31 and 25 (OH) D between the allergic rhinitis (AR), nonallergic rhinitis (NAR), and control groups and to investigate the relationship between IL-31 and 25 (OH) D.
Methods: We recruited 59 children with only rhinitis and 33 controls without any allergic diseases. Serum IL-31 and 25(OH) D levels were assayed using an enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively. The patients were considered to have atopic sensitization if the levels of serum specific IgE to inhalant allergens as assessed using immunoCAP were ≥0.35 IU/mL or if they tested positive for one or more allergens by the skin prick test.
Results: Of children with rhinitis, 25 had nonatopy (NAR), and 34 children had atopy (AR). Serum 25(OH) D levels were significantly lower in the rhinitis group than in the control group, while there was no significant difference serum 25(OH) D levels between the AR and NAR groups. Children with rhinitis demonstrated higher serum IL-31 levels than controls; however, there was no difference in serum IL-31 levels between the AR and NAR groups. Serum 25(OH) D levels were inversely correlated with serum IL-31 levels and blood eosinophil counts. On the other hand, serum 25(OH) D levels were not correlated with total serum IgE levels.
Conclusion: Serum 25(OH) D and IL-31 may play a role in the pathogenesis of rhinitis via mechanisms other than IgE-related pathway.
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KEYWORD
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Allergic rhinitis, Nonallergic rhinitis, Interleukin-31, 25-Hydroxyvitamin D, Vitamin D
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